Effects of Some Tranquillizing Agents on Brain Noradrenaline and Dopamine Levels of Shocked Rats.

佐藤 哲男 ・岩本 多喜男 ・徳光 幸子 * Though this is not a tranquillizing drug , it is used here as an antiserotonin agent. In the previous report (1), the authors showed that the brain noradrenaline level in rat was induced to elevation, in the state of electric shock, compared with that in non-treated animals. On the other hand, pretreatment with some tranquil lizing;,agents, chlorpromazine, azacyclonol inhibited the increase of noradrenaline level in shocked state, while, chlordiazepoxide had no effect on noradrenaline level. In addition to the previous paper, other tranquillizing agents, tetrabenazine, thiori dazine and cyproheptazine* were employed in this experiment in order to examine their effect on both noradrenaline and dopamine levels of rat brain in abnormal en vironment, i.e., electrically shocked state.